Carol Giometti
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Bldg: 202 Room: LA125
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- Knox College B.A. 1972 Biology
- Rush Hospital MT 1973 Medical Technology *
- University of Illinois Ph.D. 1978 Biochemistry
*Certified Medical Technologist; Internship at Rush-Presbyterian St. Luke's Hospital,Chicago, 1972/73
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Director, Biosciences Division, Argonne National Laboratory |
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Senior Biochemist and Group Leader, Protein Mapping Group, Argonne National Laboratory |
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Biochemist and Group Leader, Protein Mapping Group, Argonne National Laboratory |
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Acting Division Director, Biosciences Division, Argonne National Laboratory |
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Assistant Biochemist, Protein Mapping Group, Argonne National Laboratory |
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Assistant Biochemist, Molecular Anatomy Program, Argonne National Laboratory |
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Assistant Biologist, Molecular Anatomy Program, Argonne National Laboratory |
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Postdoctoral Appointee, Molecular Anatomy Program, Argonne National Laboratory |
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Teaching Assistant,University of Illinois at the Medical Center, Chicago |
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Medical Laboratory Intern, Rush-Presbyterian St. Luke's Hospital, Chicago |
> Research Highlights:
My current research interests include (1) the detection and characterization of changes in protein expression within biological systems in response to environmental stimuli and disease processes, (2) the development of new approaches to the separation and characterization of proteins in complex mixtures that are compatible with high-throughput research applications, (3) the construction of databases for protein expression data, and (4) the interfacing of the protein expression databases with gene expression and gene sequence databases. Two-dimensional gel electrophoresis (2DE) and HPLC/MS-MS are used as tools for protein separations and identification of specific proteins. Development of methods for separation of native proteins (classical 2DE is designed for the separation of denatured proteins) that will allow the detection and characterization of protein-protein interactions and protein function are in progress as are efforts to isolate and characterize proteins from environmental samples. Data from this research is being stored using a relational database interfaced with World Wide Web capability for interrogation of the protein expression and identification data in the context of genome sequence information.
See:
http://proteomeweb.anl.gov
http://gelbank.anl.gov
Zhang; Jian-Shi, Giometti; Carol S., Tollaksen; Sandra L. 1987. Electrophoretic extraction of proteins from two-dimensional electrophoresis gel spots. No. 4,824,547
- Young Investigator Award in Clinical Chemistry, 1984
- American Association of University Women Scholarship, 1977-1978
