Lee Makowski
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> Research Highlights:
My Research interests include molecular recognition, in particular, the process by which
proteins bind small molecule ligands and drugs; structure of large, macromolecular assemblies,
including development of novel methods for the analyses of these structures; and development
of high-throughput methods for molecular biology and biochemistry. Recently we have developed
a novel statistical measure of the diversity of combinatorial libraries and used it to estimate the
complexity of phage-displayed peptide libraries. We are currently using this statistical approach
to quantitate sequence diversity in multiply-aligned protein sequences.
- 1976 Ph.D. Electrical Engineering, Massachusetts Institute of Technology
- 1973 M.S. Electrical Engineering, Massachusetts Institute of Technology
- 1971 B.S. Physics, Brown University
- 2007- Senior Scientist, Biosciences Division, Argonne National Laboratory
- 2000-2007 Director, Biosciences Division, Argonne National Laboratory
- 2001- Senior Fellow, Computation Institute, University of Chicago
- 1999-2000 Program Director, Materials Research Science and Engineering Centers , Division of Materials Research, N.S.F.
- 1997-1999 Program Director, Instrumentation and Instrumentation Development , Division of Biological Infrastructure, N.S.F.
- 1993-1999 Professor, Department of Biological Sciences, and Department of Chemistry, Florida State University
- 1993-1997 Director, Institute of Molecular Biophysics and Program in Structural Biology, Florida State University
- 1991-1993 Professor, Dept. of Physics, Boston University
- 1987-1991 Associate Professor, Dept. of Physics, Boston University
- 1982-1992 Guest Assistant Scientist, Brookhaven National Laboratories
- 1980-1987 Assistant Professor, Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons of Columbia University
- 1978-1980 Senior Research Associate, Structural Biology Laboratory, Brandeis University
- 1976-1978 N.I.H. Postdoctoral Fellow, Structural Biology Laboratory Brandeis University, Waltham, Massachusetts .
- 2005- Member, UIC College of Engineering Advisory Board
- 2000-2007 Senior Advisor, Nanoframes LLC
- 2001-2003 Member, Executive Board; Computation Institute, University of Chicago
- 2001 Guest Editor, 'Hot Topics' Issue, Combinatorial Chemistry and High Throughput Screening; March, 2001.
- 2000 Organizing Committee, 'Phage Display, Structure and Assembly'; Vancouver, 9/2000.
- 1999-2000 Consultant, EntreMed Inc., Rockville, Md.
- 1999- Member, BioCAT Advisory Committee, Advanced Light Source, Argonne Natl. Lab.
- 1998 Member, SMIG Working Group on Cost Sharing, NSF
- 1997-1999 Member, American Physical Society Biological Physics Prize Committee
- 1997 Organizer; Conference on 'Quasi-equivalence: Motion and Adaptability in Living Molecules' January, Tallahassee, Fl.
- 1996-1997 Program Director; NSF Research Training Group in 'Structural Biology of Macromolecular Assemblies' ( Florida State University)
- 1992 Program Chair, Biophysical Society Meeting, Houston.
- 1990-1993 Executive Council, Biophysical Society
- 1990-1993 Program Director; NIH Training Grant; Structural Biology ( Boston University)
- 1989 Organizing Committee, Workshop in 'Fiber Diffraction from Biological Macromolecules, May, Fall Creek Falls
- 1988-1994 Member, Biophysics Program Advisory Panel, NSF
- 1988-1993 Council Member, Biophysical Society
- 1987-1993 Associate Editor, Biophysical Journal
- 1985 Organizing Committee, 4th Biophysical Discussion,Macromolecular Assemblies Analyzed by Converging Structural Techniques, November, Airlie Va.
- 1981-1986 Irma T. Hirschl Career Scientist Award
- 1978-1982 Alfred P. Sloan Research Fellow
- Makowski, L., H.F. Batliwala, T. Somasundaram and E.E. Uzgiris (1994) Method and
system for allowing increased migration across a lipid bilayer.
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