Functional Genomics | Biosciences Division

Diane J. Rodi

	Diane J. Rodi Cell / Molecular Biologist Bldg: 202 Room: B277 Email: drodi@anl.gov Phone: (630) 252-3963 Biographical Sketch Publications Lab Personnel
> Research Highlights
	NCI Cancer Protein Biomarkers This project strategically advances NCI's mission to eliminate the suffering and death due to cancer by developing, refining, and deploying the advanced technologies and resources needed for the systematic development of cancer proteomics. Proteomics represents the most promising approach to detect cancer early and develop targeted therapies and preventives for the complex of diseases that compromise cancer ...

	Solution Structural Biology The high-resolution, three-dimensional structure of a protein provides an important basis for evaluating protein function. Unfortunately, high resolution structural imaging via macromolecular crystallography and NMR spectroscopy is applicable only to a relatively small proportion of the proteome and published success rates for high-throughput (HTP) structural genomics centers are currently less than 2% ...

	RELIC - REceptor LIgand Contacts In spite of the large number of functional genomics tools currently available, typically 40% of predicted ORFs remain unidentified in terms of function, even after the application of sequence similarity comparisons, genomic context analysis, profile comparisons across multiple genomes, and structural genomics methods. Characterization of the type(s) of small molecules to which an ORFan ...

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