Functional Genomics | Biosciences Division

Metalloproteomics

	David Glesne STA Email: glesne@anl.gov Biographical Sketch Publications Lab Personnel
> Research Highlights

	Use of synchrotron-derived x-rays for in situ mapping and quantitative analysis of metal ion distributions in eukaryotic cell systems Our laboratory is currently conducting research into the role essential metals play in regulating proteins during maturation and differentiation of eukaryotic cells. Specifically, we are interested in the role copper plays in regulating angiogenesis and branching morphogenesis of human endothelial cells. read more

	Development of cell biology tools for X-ray fluorescence analysis Currently, scan output provide metal mapping data but no protein and cellular context information is provided. We are developing tools for the visualization of organelles and individual proteins that will allow for their visualization by x-ray approaches. read more

	Development and use of technologies for the high-throughput proteome-wide separation and identification of metalloproteins. While the literature abounds with examples of metalloproteins that are involved in essential cellular processes, there are almost certainly numerous other proteins and peptides not yet identified which are involved in these morphogenic processes that bind metals such as copper, zinc, manganese and nickel. read more

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