Molecular and Systems Biology
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Experimental Annotation of Function The abundance of genomic sequence data from different organisms provides an opportunity to accelerate our understanding of protein structure and function. However, optimal utilization of this genomic information will require the development of high throughput methods for the ...  Read more |
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Interventional Biology A “marriage” of bioscience and nano-technology will fundamentally alter both life and material sciences. On the one hand, due to millions of years of evolution, nature produces complex multifunctional objects with widely disparate molecular constituents organized over many different length scales. Read more |
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Metalloprotein Research An estimated one third of all proteins bind metal ions, and many of these proteins have regulatory or catalytic functions. Developing and employing methods to identify and characterize these metalloproteins will give us a better understanding of their roles. Read more |
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Proteomics Proteomics is an area of research that seeks to identify the proteins in a biological system at a specific point in time and to understand variations in the abundance of those proteins as a function of cell growth environments. Proteomics researchers isolate, separate, identify, and characterize the proteins from biological systems to better understand what factors influence the relative abundance of those proteins, what functions/metabolic processes are represented by those proteins, and how those functions/metabolic processes are regulated. Read more |
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Clinical Proteomics and Biomarker Discovery This project strategically advances NCI's mission to eliminate the suffering and death due to cancer by developing, refining, and deploying the advanced technologies and resources needed for the systematic development of cancer proteomics. Proteomics represents the most promising approach to detect cancer early and develop targeted therapies and preventives for the complex of diseases that compromise cancer. Read more |
