Hybridized Phage

Liaohai Chen and Brett Engelmann
Biosciences Division, ANL

Self assembly, biological affinity, and controlled chemistry have been combined in the formation of hybridized T7 bacteriophage nanoparticles.  A novel controlled chemistry reactor has been developed by our group with the tunable ability to selectively bind to target biomolecules.  The applications for such a bionanocomposite are vast.  They include biosensing, targeted drug/gene delivery, image contrast enhancement, and nanoassembly.

Fig.1

(A) TEM image showing ordered alignment of T7 phage particles with M13 filamentous phage. (B) TEM image of technetium-99 hybridized phage.

Relevant Publications

(1)  Liu, C.M., Jin, Q., Sutton, A., Chen, L. (2005) A Novel Fluorescent Probe: Europium Complex Hybridized T7. Bioconjugate Chem. 16, 1054-1057.