Frank Collart

Bldg: 202 Room: D129 Email: fcollart@anl.gov Phone: (630) 252-4859     ~ Education Professional Experience Publication List Research Highlights Patents

> Education:

• 1984, Ph.D, Medical Sciences, Medical College of Ohio
• 1982, M.S., Chemistry, Bowling Green State University
• 1977, B.A., Chemistry, Bowling Green State University

> Professional Experience:

• Robotic Molecular Biology Facilities Manager, Biosciences Division,Argonne National Laboratory.
• Gene Cloning and Expression Group Leader, Midwest Center for Structural Genomics, Argonne National Laboratory.
• 1994 - present: Molecular Biologist; Biosciences Division, Argonne National Laboratory.
• 1989 - 1994: Assistant Molecular Biologist; Division of Biological and Medical Research (BIM), Argonne National Laboratory.
• 1984 - 1989: Postdoctoral Appointee, Supervisor: Dr Eliezer Huberman Division of Biological and Medical Research (BIM), Argonne National Laboratory.

> Memberships in professional societies:

• Sigma Xi
• American Association for Cancer Research

> Review committees:

• Medical Advisory Board of the Leukemia Research Foundation    1996-Present
• American Cancer Society, Illinois Division Research Advisory Committee   1998-Present

> INVITED LECTURES: (last 3 years)

1. Development of Genome-Scale Expression Methods, 2005 Genomics:GTL Workshop, February 9, 2005, Washington DC.
   
2. Argonne: Overview and Opportunities, JETRO Biotechnology International Symposium, October 20, 2003, Osaka, Japan.
   
3. Methods for Genome Scale Protein Expression, Purdue University, December 10th, 2003.
   
4. Expression of secretory/periplasmic proteins and “soluble” domains of membrane proteins, NIH Protein Production Bottlenecks Meeting.  Washington DC, March 28-31, 2004
   
5. Challenges for Automation and Expression Systems, Protein Production and Characterization Workshop, Biosciences Division, Argonne National Laboratory, Argonne, IL, May, 29th, 2004.
   
6. Evaluation of High Throughput Methods for Cloning and Expression of Soluble Domains Session 1.09 (Fresh Approaches to Express and Purify Biomolecules) of the 2004 American Crystallographic Association Annual Meeting, Chicago, IL, July 17-22, 2004.
   
7. High Throughput Expression Strategies for Structural and Functional Genomics, Methods in Protein Structure Analysis, University of Washington Campus, Seattle, WA USA, August 29 - September 2, 2004.
   
8. ANL Perspective on Protein Production, Pacific Northwest National Laboratory, Richland, WA, September 3rd, 2004.
   
9. Protein Production at ANL and Shewanella Federation Collaborations, Shewanella Federation Meeting, MBL Club in Woods Hole, MA, September 12-13th, 2004.
   
10. Argonne: Overview and Biotechnology Opportunities, Kazusa DNA Research Institute, Chiba Prefecture, Japan, September 30th 2004.High Throughput Strategies for Gene Cloning and Expression. Twelfth Users Meeting for the Advanced Photon Source, Argonne, IL, April 29, 2003
    
11. High Throughput Gene Cloning and Expression for Structural Genomics. Marcus Evans Conference: High Throughput Screening for Drug Discovery, Boston, MA, February 25-27, 2003.
    
12. High Throughput Methods for Cloning and Expression. CHI Protein Expression conference, San Diego, CA, January 13-14, 2003.
    
    
13. High Throughput Gene Cloning and Expression for Structural Genomics. Illinois Institute of Technology, Chicago, IL, November 25, 2002.
    
14. High Throughput Methods for Cloning and Expression. IBC Protein-Protein Interactions Meeting.  Newark, NJ. November 4-6, 2002.
    
15. High Throughput Methods for Cloning and Expression. KaroBio Inc, Durham, NC., September 13, 2002.
    
16. High Throughput Gene Cloning and Expression for Structural Genomics. Northwestern University, Evanston, IL, April 17, 2002.
    
17. High Throughput Gene Cloning and Expression - Opportunities and Limitations. Abbott Laboratories, Abbott Part, IL, March 22, 2002
    
18. Automation Bottlenecks in Cloning and Expression. NIH Protein Production Bottlenecks Meeting.  Washington DC, March 7-8, 2002

> PATENTS: (Awarded)

1. US Patent 5,665,583: issue date September 9, 1997.  Methods and Materials Relating to IMPDH and GMP Production.  .  F.R Collart and E. Huberman.
   
2. US Patent 6,147,194: issue date November 14, 2000.  Eukaryotic IMPDH polynucleotide and antibody compositions. F.R Collart and E. Huberman.
   
3. US Patent 6,153,398: issue date November 28, 2000.  Method to identify specific inhibitors of IMP dehydrogenase.  F.R Collart and E. Huberman.
   
4. US Patent 6,479,628: issue date November 12, 2002.  Methods and Materials Relating to IMPDH and GMP Production (Continuation).  Inventors, F.R. Collart and E. Huberman.  Inventors: F.R. Collart, E. Huberman.
   
5. US Patent 6,826,488, issue date November 30, 2004, Crystals, molecular complexes, and methods of developing lead compounds for inhibitors of bacterial IMPDH.  Inventors: F.R. Collart, E. Huberman, A. Joachimiak, E.M. Westbrook, and R. Zhang.
   
   
   INVENTION REPORTS:

• ANL-IN-86-72 Plant or Animal Organism with Increased Amounts of GMP. F.R. Collart and E. Huberman
• ANL-IN-88-18  Synthetic DNA Construct, Cells, and Artificial Animals F.R. Collart and E. Huberman
• ANL-IN-90-66 Method for Detecting Tumor Cells. F.R. Collart and E. Huberman
• ANL-IN-94-032 New Material Relating to IMPDH and GMP Production. F.R. Collart, E. Huberman, J. Osipiuk, and J. D. Trent
• ANL-IN-94-068 DNA sequence from Arabisopsis thaliana. F.R. Collart, E. Huberman, J. Osipiuk, and J. D. Trent
• ANL-IN-97-053 A Method to Identify Specific Inhibitors of IMP Dehydrogenases. F.R. Collart and E. Huberman
• ANL-IN-98-058 A Method to Design Drugs for the Inhibition of Microbial Growth. F.R. Collart, E. Huberman, A. Joachimiak, E.M. Westbrook, and R. Zhang
• ANL-IN-00-014 Universal Genomic Detector: A Generic Method for Identification and Comparison of Genomic Material. F. Stevens and F.R Collart.
• ANL-IN-00-02 Inhibitors of microbial IMPDH enzymes F.R. Collart, E. Huberman, A. Joachimiak, E.M. Westbrook, and R. Zhang
• ANL-IN-00-083 Method to optimize recombinant protein expression F.R. Collart, M. Donnelly, and L. Stols.
• ANL-SF-03-22 Express Primer Tool for High-throughput Gene Cloning and Expression F.R. Collart, Gu, M., Laible, P. D., Scott, H.N, Stevens, F.J., and Yoon, J.