Brian K. Kay

Email: bkay@anl.gov STA     ~ Education Professional Experience Publication List Research Highlights Full Information

> Education:

• University of Chicago, Chicago, IL USA
  1971-1975: B.A. Biology (with honors) - 1975
• Yale University, New Haven, CT USA
  1975-1980: Ph.D. Biology - 1980

> Professional Experience:

• Senior Participant and IRG co-leader, Chicago Materials Research Center (MRSEC), June 2004 – present.
• Adjunct Professor, Curriculum on Genetics, University of Chicago, April 2003 – present.
• Senior Biochemist & Group Leader, Argonne National Laboratory, Argonne, IL, October 2001-present.
• Professor, Department of Pharmacology, University of Wisconsin-Madison, July 2000-September 2001.
• Associate Director, Biotechnology Center, University of Wisconsin-Madison, WI, March 1999-September 2001.
• Molecular Interaction Facilities Director, Biotechnology Center, University of Wisconsin-Madison, WI, March 1999-September 2001.
• Associate Professor, Department of Pharmacology, University of Wisconsin-Madison, WI, July 1997-June 2001.
• Co-founder, Novalon Pharmaceutical Corporation, Research Triangle Park, NC,
  May 1996-May 2000.
• Sabbatical Fellow, GlaxoWellcome Research Institute, Research Triangle Park, NC, September 1995 - March 1996. In the laboratory of Dr. H. Mario Geysen.
• Associate Professor, Department of Biology, University of North Carolina, Chapel Hill, NC, 1991-1997.
• Assistant Professor, Department of Biology, University of North Carolina, Chapel Hill, NC, 1984-1991.
• Staff Fellow, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD, 1982-1984. In the laboratories of Drs. Keiko Ozato and Igor Dawid.
• Postdoctoral Research Fellow, Anna Fuller Research Foundation, National Cancer Institute, Bethesda, MD, 1980-1982. In the laboratory of Dr. Igor Dawid.
• Predoctoral Trainee, NIH, Department of Biology, Yale University, New Haven, CT, 1975-1980. In the laboratory of Dr. Joseph Gall.

> Patents

• Kay, B.K. and Fowlkes, D.M. (US Patent # 5,498,528) Totally Synthetic Affinity Reagents
• Smith, J. and Kay, B.K. (US Patent # 5,596,079) Mimetics of Senescent Cell-Derived Inhibitors of DNA Synthesis
• Kay, B.K. and Fowlkes, D.M. (US Patent # 5,625,033) Totally Synthetic Affinity Reagents
• Kay, B.K., Fowlkes, D.M., Adey, N.B. and Sparks, A.B. (US Patent # 5,747,334) Random Peptide Library
• Kay, B.K. and Fowlkes, D.M. (US Patent # 5,844,076) Totally Synthetic Affinity Reagents
• Kay, B.K. and Adey, N.B. (US Patent # 5,852,167) Totally Synthetic Affinity Reagents
• Kay, B.K., Fowlkes, D. M., and Pirozzi, G. (US Patent # 6,011,137) Identification and isolation of novel polypeptides having WW domains and methods of using same.
• Sparks, A.B., Hoffman, N.B., Fowlkes, D.M., and Kay, B.K., (Australian Patent # 711141) Polypeptides having a functional domain of interest and methods of identifying and using same,
• Kay, B.K. and Fowlkes, D.M. (Japanese patent #3,043,407) Totally Synthetic Affinity Reagents.
• Kay, B.K. and Fowlkes, D.M. (Canadian patent #2,155,185) Totally Synthetic Affinity Reagents.
• Kay, B.K., Sparks, A.B., Thorn, J.M., Quilliam, L, and Der, C.J. (US Patents # 6,303,574; #6,703,482) Src SH3 binding peptides and methods for isolating and using same.
• Pirozzi, G., Kay, B.K., and Fowlkes, D. M. (Australian Patent # 733650) Identification and isolation of novel polypeptides having WW domains and methods of using same.
• Fowlkes, D.M. and Kay, B.K. (European Patent #0515516) Methods for identifying heterofunctional fustion proteins.
• Sparks, A.B., Kay, B.K., Thorn, J.M., Quilliam, L.A., Der, C.J., Fowlkes, D.M., and Rider, J.E. (US Patent #6,432,920) Nck SH3 binding peptides.
• Rubin, J., Uren, A., Horwood, M.T., Gillespie, N.J., Kay, B. K. and Weisblum, B. (PCT 02/055547) SFRP and peptide motifs that interact with SFRP and methods of use.
• Fowlkes, D.M. Kay, B.K, Frelinger; J.A., and Hyde-DeRuyscher, R.P. (US Patent # 6,617,114) Identification of drug complementary combinatorial libraries
• Sparks, A.B., Hoffman, N., Kay, B.K., Fowlkes, D.M., McConnell, S.J. (US Patent #6,709,821) Polypeptides having a functional domain of interest and methods of identifying and using same.
• Sparks, A.B., Kay, B.K., Thorn, J.M, Quilliam, L.A., Der, C. J., Fowlkes, D.M, and Rider, J.E. (European Patent #897392) Peptides binding SH3 domain of cortactin and their use.

> Honors/Awards

• Societies:
  American Society for Cell Biology
  American Chemical Society
  American Society for Pharmacology and Experimental Therapeutics
  
• Offices: Duke University Combinatorial Sciences Center (Board of Directors, 1995-1999)
  North Carolina Peptide Bond Society (President, 1996-1997)

> Grant Support

• NIH, $18,000,000, Co-PI with Drs. John Markley, George Phillips, Ivan Rayment, and Michael Sussman; 11/1/01-10/31/06
  The Three-dimensional Structure of Arabidopis thaliana Proteins
• Laboratory Division Research Development, DOE, $3,000,000; 10/1/01-9/30/05, PI
  Functional Genomics Initiative
• Defense Advanced Research Projects Agency (DARPA), #8C67400, $250,000; 03/01/03-09/30/05, PI: Dr. Liaohai Chen
• Sensors based on resonant oscillation of magnetic phage with high affinity and specificity for target molecules
  NIH, $250,000; 03/01/03-9/31/05, Co-PI with Drs. Liaohai Chen, Heinrich Jaeger, and Rong Wang
  Nanotechnology for systems biology of neural stem cells
• NIH RCE, 1 U54 AI057153-01, $90,000; 10/1/03-9/30/04
  PI: Olaf Schneewind, Co-PIs: Andrzej Joachimiak, Natalia Maltsev, Dominique Missiakis, and Phil Hanna
  Therapeutic inhibition of Bacillus anthracis pathogenesis
• ANL Laboratory Directed Research and Development Program, #2004-240, $100,000;
  10/01/04-9/30/05, Co-PI: Carol Giometti
  Phage-display and Cardiac Proteomics
• Office of Naval Research, Grant #N00014-04-1-0796, $40,000; 9/6/04-4/30/07, PI: Dr. Terry Vanden Hoek, Co-PI with Dr. Lance Becker
  Proteomic development of molecular vital signs: mapping a mitochondrial injury severity score to triage and guide resuscitation of hemorrhagic shock