Lee Makowski

Bldg: 202. Room:  L114 E-mail: lmakowski@anl.gov Phone: (630) 252-3819     ~ Education Professional Experience Publication List Research Highlights Patents Full Information

> Education:  

• 1976 Ph.D. Electrical Engineering, Massachusetts Institute of Technology
• 1973 M.S. Electrical Engineering, Massachusetts Institute of Technology
• 1971 B.S. Physics, Brown University

> Professional Experience:

• 2000 Director, Biosciences Division, Argonne National Laboratory  
• 2001Senior Fellow, Computation Institute, University of Chicago  
• 1999-2000 Program Director, Materials Research Science and Engineering Centers , Division of Materials Research, N.S.F.
• 1997-1999 Program Director, Instrumentation and Instrumentation Development , Division of Biological Infrastructure, N.S.F.
• 1993-1999 Professor, Department of Biological Sciences, and Department of Chemistry, Florida State University  
• 1993-1997 Director, Institute of Molecular Biophysics and Program in Structural Biology, Florida State University  
• 1991-1993 Professor, Dept. of Physics, Boston University  
• 1987-1991 Associate Professor, Dept. of Physics, Boston University
• 1982-1992 Guest Assistant Scientist, Brookhaven National Laboratories  
• 1980-1987 Assistant Professor, Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons of Columbia University  
• 1978-1980 Senior Research Associate, Structural Biology Laboratory, Brandeis University
• 1976-1978 N.I.H. Postdoctoral Fellow, Structural Biology Laboratory Brandeis University, Waltham, Massachusetts .

> Professional Activities:

• 2000 Senior Advisor, Nanoframes LLC  
• 2001 Member, Executive Board; Computation Institute, University of Chicago
• 2001 Guest Editor, 'Hot Topics' Issue, Combinatorial Chemistry and High Throughput Screening; March, 2001.  
• 2000 Organizing Committee, 'Phage Display, Structure and Assembly'; Vancouver, 9/2000.  
• 1999-2000 Consultant, EntreMed Inc., Rockville, Md.
• 1999 Member, BioCAT Advisory Committee, Advanced Light Source, Argonne Natl. Lab.
• 1998 Member, SMIG Working Group on Cost Sharing, NSF
• 1997-1999 Member, American Physical Society Biological Physics Prize Committee  
• 1997 Organizer; Conference on 'Quasi-equivalence: Motion and Adaptability in Living Molecules' January, Tallahassee, Fl.
• 1996-1997 Program Director; NSF Research Training Group in 'Structural Biology of Macromolecular Assemblies' ( Florida State University)
• 1992 Program Chair, Biophysical Society Meeting, Houston.
• 1990-1993 Executive Council, Biophysical Society  
• 1990-1993 Program Director; NIH Training Grant; Structural Biology ( Boston University)  
• 1989 Organizing Committee, Workshop in 'Fiber Diffraction from Biological Macromolecules, May, Fall Creek Falls
• 1988-1994 Member, Biophysics Program Advisory Panel, NSF
• 1988-1993 Council Member, Biophysical Society  
• 1987-1993 Associate Editor, Biophysical Journal  
• 1985 Organizing Committee, 4th Biophysical Discussion,Macromolecular Assemblies Analyzed by Converging Structural Techniques, November, Airlie Va.
• 1981-1986 Irma T. Hirschl Career Scientist Award  
• 1978-1982 Alfred P. Sloan Research Fellow

> Research Highlights:

My Research interests include molecular recognition, in particular, the process by which
proteins bind small molecule ligands and drugs; structure of large, macromolecular assemblies,
including development of novel methods for the analyses of these structures; and development
of high-throughput methods for molecular biology and biochemistry. Recently we have developed
a novel statistical measure of the diversity of combinatorial libraries and used it to estimate the
complexity of phage-displayed peptide libraries. We are currently using this statistical approach
to quantitate sequence diversity in multiply-aligned protein sequences.

> Patents:  

Makowski, L., H.F. Batliwala, T. Somasundaram and E.E. Uzgiris (1994) Method and
system for allowing increased migration  across a lipid bilayer. U.S. Patent #5,284,588,
Feb. 8, 1994