The Center for Structural Genomics of Infectious Diseases (CSGID) is funded by the National Institutes of Health (NIH) and National Institute of Allergy and Infectious Diseases (NIAID). The goal is to apply state-of-the-art high-throughput structural biology technologies to experimentally characterize the three dimensional atomic structure of targeted proteins from pathogens in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious diseases. The three-dimensional structure of proteins will assist drug design and development by yielding direct insights into the target molecular mechanisms, in interaction with other biological molecules, or with synthetic compounds, in order to improve selectivity, specificity and optimize drug development in a rational way. The CSGID is a consortium of eight institutions: Northwestern University, University of Chicago, J. Craig Venter Institute, University College London, University of Toronto, University of Virginia, UT Southwestern Medical Center at Dallas and Washington University School of Medicine and it utilizes facilities at Argonne’s Biosciences Division and the Advanced Photon Source user facility for protein production, crystallization, data collection, and structure determination. The consortium has determined over 500 structures.

For more information, visit the Center for Structural Genomics of Infectious Diseases website at http://csgid.org/csgid/.

Contact: Andrzej Joachimiak, andrzejj@anl.gov