Structural Biology
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The Midwest Center for Structural Genomics The Midwest Center for Structural Genomics (MCSG) is a consortium of the Argonne National Laboratory, European Bioinformatics Institute, Northwestern University, University of Toronto, Washington University, University College London, University of Virginia and the ...  Read more |
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Center for Structural Genomics of Infectious Diseases CSGID applies state-of-the-art high-throughput (HTP) structural biology technologies to experimentally characterize the three dimensional atomic structure of targeted proteins from pathogens in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious diseases ... Read moreResearchers from the Biosciences division are collaborating on this project. |
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Structural Correlates of Protein Function We focus on the characterization and structure determination of proteins. Our ultimate goal is to understand how the structures and functions of proteins are related. The samples that we work with include proteins that are important in (1) bioremediation (multiheme cytochromes, heme based sensors), (2) biofuels (hydrolytic enzymes), (3) human health (immunoglobulin light chains), and (4) photosynthesis (reaction center) ... Read more |
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Membrane Protein Engineering Membrane-bound proteins pose particular challenges for biochemical and biophysical studies. Our development of novel expression systems and stabilizing reagents for membrane proteins advances the potential for study of these highly specialized molecular systems. Read more |
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Wide-angle X-ray Scattering The high-resolution, three-dimensional structure of a protein provides an important basis for evaluating protein function. Unfortunately, high resolution structural imaging via macromolecular crystallography and NMR spectroscopy is applicable only to a relatively small proportion of the proteome and published success rates for high-throughput (HTP) structural genomics centers are currently less than 2% ... Read more |
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Great Lakes Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research Projects in the Great Lakes RCE are multi-year, multi-disciplinary studies aimed at the development of new vaccines or therapies against diseases caused by agents that can be used as biological weapons. Research Projects provide the backbone of scientific study in the consortium ... Read MoreResearchers from the Biosciences division are collaborating on this project. |
