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Membrane Protein Engineering


Philip Laible
Biophysicist

Bldg: 202. Room: B133
E-mail: laible@anl.gov
Phone: (630) 252-4875

Biographical Sketch

> Research Highlights
Membrane protein expression system
The cell membrane serves as the interface between an organism and its environment, and internal membranes in eukaryotes separate functional compartments within cells. Proteins inserted in these membranes carry out many essential biological processes including uptake of nutrients, excretion of wastes, signal transduction, and response to external stimuli. read more
Nanobiology: Biomimetic nanostructures for membrane protein structure and function
Membrane proteins facilitate many key cellular processes including signal recognition, ion transport, and energy transduction. The study and subsequent exploitation of membrane proteins has, however, received considerably less attention than have soluble proteins, primarily due to difficulties encountered in stabilizing these biological molecules after they are removed from their native lipid bilayer environment. read more
Overexpression of Human Immunodeficiency Virus (HIV) coreceptors in Rhodobacter
Structural information revealing the interactions that occur between host and viral proteins in HIV infection is growing. The HIV coreceptors CCR5 and CXCR4 represent promising untapped opportunities for anti-HIV drug development. read more
Photosynthetic reaction center: A novel quantum electronic circuit element
Living cells contain a large variety of biomolecular complexes which self-assemble, recognize and control each other. These nanoscale devices, referred to as bionanodevices, perform critical cell functions such as gene expression, energy conversion, motion, signaling and metabolism. read more

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