Homology Analysis for Structure, Function, and Malfunction A major challenge for structural biology is to maximize the information content in the amino acid sequence of a protein. The information relevant to functional genomics includes function(s), stability, and interaction partners. For two proteins closely linked by evolution, comparison of ...Read more
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Structure and Function of Membrane Proteins
For instance, membrane bound proteins pose particular challenges for biochemical and biophysical studies. Our development of novel expression systems for membrane proteins advances the potential for study of these molecualr systems and provides us with special Read more
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Conformational Diseases and Protein-Protein Interactions The term "conformational disease" is a relatively new name for a family of diseases caused by protein misfolding and aggregation. Diseases associated with protein aggregation include the amyloidoses, such as immunoglobulin light chain amyloidosis and Alzheimer's disease, Huntington's disease ...Read more
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Structural Correlates of Protein Function Geobacter sulfurreducens is a bacteria useful in bioremediation. The three-heme 9.6 kDa c7 cytochrome, is one of many multi-heme cytochromes encoded by the genome of this organism. This small cytochrome is part of a reduction cascade in vivo and it can reduce metal oxides and metal ions in vitro ...Read more
