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 Structural Genomics
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The Structural Biology Center
The Structural Biology Center (SBC) is a national user facility for macromolecular crystallography at the Advanced Photon source. The facility uses advanced instrumentation , state-of-the-art software and methods and high throughput technologies. SBC is capable of ...  Read more |
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The Midwest Center for Structural Genomics
The Midwest Center for Structural Genomics (MCSG) is a consortium of the Argonne National Laboratory, European Bioinformatics Institute, Northwestern University, University of Toronto, Washington University, University College London, University of Virginia and the ... Read more |
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General Medicine and Cancer Institutes Collaborative Access Team
The General Medicine and Cancer Institutes Collaborative Access Team (GM/CA-CAT) at the Advanced Photon Source (APS) is a part of the Biosciences Division (BIO), Argonne National Laboratory (ANL). The GM/CA CAT has been established by ...Read more |
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Structural genomics attempts to provide the link between the vast amount of genomic sequence data that is being generated and the structure of the proteins which these genomes encode. The eventual goal of the project is to obtain a complete database of unique folds in proteins such that we will have the ability to predict the three-dimensional structures of all proteins from their gene sequences. There are many steps in this process and we are attacking the majority of them in new and efficient ways in the Biosciences division, including the use of high-throughput methodology (robotics and MAD-phased structure determination). Check out MCSG and SBC for more information regarding:
- the selection of gene sequence targets,
- the cloning and expression of target polypeptides,
- the crystallization of purified protein by robots,
- x-ray data collection at the SBC
- structure determination of MAD-phased data sets,
- and a "structural genomics" understanding the resulting structures.
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